Nippenose Township is a township in Lycoming County, Pennsylvania. The population was 729 at the 2000 census. It is part of the Williamsport, Pennsylvania Metropolitan Statistical Area.

Nippenose Township is on the south shore of the West Branch Susquehanna River in western Lycoming County. It is bordered by the river to the north, Susquehanna and Bastress Townships to the east, Limestone Township to the south, and Clinton County, Porter Township and Jersey Shore to the west.

Nippenose Township was originally formed as part of Northumberland County in 1786 by a session of the Northumberland County court that was held in Sunbury. It did not become part of Lycoming County until Lycoming County was also formed from Northumberland County in 1795. Nippenose Township was originally much larger than it is today. It spread over parts of what are now, Clinton, Centre and Lycoming Counties. The population of Nippenose Township was 588, in 1890, compared to the slightly higher population of 729 as of the 2000 census.

The story behind the name of Nippenose Township is unclear. There are two competing stories. One states that it is named for the Indian phrase, "Nippeno-wi", meaning a warm and genial summer like place. The other story behind the name is traces back an old Indian named Nippenose. The early settlers told the story of the old man who lingered in the valley after it was settled by whites. Apparently this man's nose had been "nipped" by exposure to the frost, hence the name "Nippenose."

The first colonial settlers arrived in the Nippenose area in 1769. Henry Clark was the first to arrive with a "warrant" to the land from the colonial Pennsylvania government. One of the most prominent eary settlers was Colonel John Henry Antes. He is thought to have arrived as early as 1772. His last name is featured prominently in place names in Nippenose Township. Antes Creek the main creek in the valley and Antes Fort a small village both bear his name. Antes built stockade around his home, his neighbors came to call it "Antes Fort" and the name has lived on to today. Colonel Antes also built a grist mill at the mouth of Antes Creek on the West Branch Susquehanna River in 1777. This mill was burned during the Revolutionary war.

During the American Revolutionary War, settlements throughout the Susquehanna valley were attacked by Loyalists and Native Americans allied with the British. After the Wyoming Valley battle and massacre in the summer of 1778 (near what is now Wilkes-Barre) and smaller local attacks, the "Big Runaway" occurred throughout the West Branch Susquehanna valley. Settlers fled feared and actual attacks by the British and their allies. Homes and fields were abandoned, with livestock driven along and a few possessions floated on rafts on the river east to Muncy, then further south to Sunbury. The abandoned property was burnt by the attackers. Some settlers soon returned, only to flee again in the summer of 1779 in the "Little Runaway." Sullivan's Expedition helped stabilize the area and encouraged resettlement, which continued after the war.

When things finally calmed down in 1792, Colonel Antes returned to Nippenose Township and rebuilt his mill this second mill was a vital link the economy of Nippenose Township until 1873 when a new mill was built in its place. Antes furthered his enterprises by building a carding and fulling mill on the banks of Antes Creek in 1810. Antes passed away in 1820. Ownership of the mills was passed onto his son-in-law Elias P. Youngman. Youngman and his sons expanded the business yet again in 1835 by adding machinery that was able to clean clover seed. Clover seed was very expensive at the time, a bushel of the seed sold for as much as $24.00. Clover was very important to farmers for providing ground cover and as a food supply for their grazing dairy cows.

The village of Antes Fort rose up around the train station that was built in Nippenose Township to service the borough of Jersey Shore which is the north and across the West Branch Susquehanna River from Nippenose Township. Antes Fort went through several name changes. The surveyor who drew up the towns plans called it "Granville." This name was seldom uses as the locals preferred to call it "Jersey Shore Station." The name Antes Fort was not bestowed on the village until 1861 when the United States Post Office established a branch there and named it in honor of Colonel Antes' stockade.